作者：Li, Ming-yue, Cheng, Lu-yan, Li, Si-chen, Fang, Yun-hong, Shao, Bin-bin, Cui, Yang-yang, Wei, Zhi-tang, Yu, Shi-jiang and Ran, Chun
摘要：BACKGROUND: The citri red mite, Panonychus citri (McGregor), is an important citrus pest worldwide, causing enormous economic losses to citrus production. Bifenazate is a widely used acaricide for controlling P. citri. The detoxification mechanism of bifenazate is not clear in P. citri. RESULTS: PcGSTMu2, a significantly upregulated GST gene, was identified by the transcriptome analysis of P. citri after bifenazate exposure. The expression level of PcGSTMu2 was significantly increased after bifenazate exposure. By using RNAi of PcGSTMu2, the susceptibility of P. citri to bifenazate was significantly increased. Protein modeling and docking of PcGSTMu2 with GSH and bifenazate indicated the potential amino acid residues for binding in the active site. Heterologous expression and in vitro functional assays further revealed that PcGSTMu2 could deplete bifenazate. CONCLUSION: These results indicated that PcGSTMu2 plays an important role in the detoxification of bifenazate in P. citri and provides the molecular foundation for understanding bifenazate metabolism in P. citri. (c) 2024 Society of Chemical Industry.
文献注录：Li, Ming-yue, Cheng, Lu-yan, Li, Si-chen, Fang, Yun-hong, Shao, Bin-bin, Cui, Yang-yang, Wei, Zhi-tang, Yu, Shi-jiang and Ran, Chun. A glutathione S transferase PcGSTMu2 involved in the detoxification of bifenazate in Panonychus citri [J]. . 2024.
报/刊名：《》，发表于2024
文献类型： [J]
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